I've got to agree with Bronko on this. I think we tend to punish ourselves needlessly with those 100/110/120 grain powder charges (yeah, I do it too). Most of us take 90% of our game at under 100 yards (usually well under), and 150 is a long shot.

For example, my Mustang shoots 420 grain cast Lee bullets in MMP orange sabots at a lowly 1425 fps with 90 grains of Pyrodex RS. Sighted in with a 125 yard zero, I'm three inches high at 75 yards (highest point of trajectory, and three and a half inches low at 150 yards. At 150 yards that bullet is still carrying over 1200 foot pounds of energy. It really drops after 150, but that will never be a factor in my hunting. What can't be killed with that load?

With the same 90 grain load, the Mustang shoots a 300 grain bullet in a tight sabot at around 1550 fps. A flatter trajectory for sure, but a deer would never know the trajectory was better. Still, I hunt with 300 grains bullets and 105 grains of T7 because that load gives me nearly 1800 fps and makes me think I have a better load.