I would like to know more about the 25.06 and the 22/250. I could always load a lighter bullet for my 30.06 if I wanted to take a shot at 300yds or closer. I dont plan on calling. I live near the NV boarder and the yotes are plentiful. I have just sat on a little hill overlooking some flat land and spotted them them way off. I really want to pick them off at 500yds or more. My buddy said a .223 would be just fine but thats the only small bore rifle he has ever shot.