ORIGINAL: stalkingbear
Since you don't reload, be SURE to use +P ammo such as Garret or Buffalo Bore. Cor-Bon is excellent ammo as well. The gun is up to it if you are. I'd want to stay within long bow range or closer for a good shot though.
Stalkingbear is right on the money here......I don't reload and I purchase my +P .45Colt from all of the above and none of them have let me down. You will be amazed at the bark the old .45Colt has when you stoke it with +P's. It really brings this old cartridge to life! Keep the range inside of 50yds and she'll do the job on any of the North American Big game.
Congrats on a fine revolver, they are built like a tank (weigh about as much too!
)