If you handload, absolutely. Ruger revolvers are tough guns that can handle "+P" .45 Colt loads nicely. There is published data for .45 Colt loads that easily meet or exceed the performance of .44 Mag loads in these strong revolvers. My Hornady book has high power .45 Colt data that I've used for light loads through my .454 Casull Super Redhawk.

Mike