I have done some testing on that, my conclusions were that with most powders the finer powder that settles to the bottom of the can has more influence on the results than weighting the one exception to this is BH209 and that is because it is extruded and coated so that the bottom of the can is the same as the top.
If you have it right as far as your load and volume measuring techniques are concerned then it won't make any difference under 150 yds at longer distances it will show up some times. Lee