I think I' m done testing on these things. God, I hope I am.
I' m shooting an old Darton at about 73lbs. pushing a 28" 2216 at about 246fps. with vanes.
If I use a Lumenock with vanes, it seems to hit about 2" lower at 20, 3-4" lower at 30 & maybe 5+?" lower at 40. (I' m not that great of a shot to clarify any better)
If I use a Lumenock with feathers, which will help your FOC, it hits maybe an inch lower at 20, 2" at 30 & maybe 4" lower at 40. (feathers slow an arrow down faster)
If I use a 2314 with the lumenock & vanes it hits in exactly the same place as my standard 2216' s. (Which is what I' ll be using)
Damn, that was the long way around to answer your question. But, simply put - Yes, they will require resighting-in unless you remember the slight impact diff.
For myself, I' ll limit ' em to the " last shot of the day" arrow. I' d use ' em exclusively but for the FOC weight offset. I' ll keep 1 or 2 in my quiver at all times.
PS: Agreed, they should help you find your deer - it' ll be the one with the red light stick' n out of ' em( or else you just found Rudolph!!!) At the least, it' ll help you find the arrow & the start of the blood trail on a pass-thru.
John