I prefer a bow, but when I gun hunt I like my 30-06 with 180gr Fusion SP ammo. After that I'll take my 300 WBY, which I know is overkill, with 180gr SP Weatherby ammo.

Surprisingly, the 30-06 will drop them in their tracks most of the time, but the 300 WBY goes through them so fast at close range they don't know they are dead until they have gone 30-40 yards.