I went with .223 in my new Savage VLP due to cheaper and more variety of available ammo as well as longer barrel life over the 22-250 and .204. I may set up a longer range gun to complement it some day, maybe in .243 or 6mm BR that can serve as a Coyote and deer gun as well. Then I could bring my .22 Savage BTVS, .223 VLP, and a .243 or 6mm BR and be covered at most ranges while my barrels cool.