RE: 22-250 for deer
I'd contrast deer hunting with .22 centerfires to concealed carry for self defense! Would you buy a .22 for self defense? Probably not! If a thug attacked you and all you had was a .22, would it work? Probably, but given a choice, I sure wouldn't want to bet my life on it!
So, I would not buy a .22 for deer hunting, when for the same price I could buy a real deer caliber!