RE: 22-250 for deer
FYI:
Federal offers a .22-250 loaded with a 60 grain Nosler Partition in its Premium Vital-Shok line. It'd work well on deer at short to medium range and would likely shoot fine in a 1:12" barrel.
Cor-Bon offers the 53 grain Barnes TSX in its DPX Hunter line which would be perfect for the typical 1:14" twist barrels. Cor-Bon also offers the 62 grain TSX in .22-250 as well, but you'd probably need at least a 1:10" twist to stabilize it.
Mike