Both are excellent deer calibers.I've used an '06 for 30 years(along with a.270),and with a 150 grain bullet I've never had one run after being hit.I know several friends that use a .308 and it does the trick plus it's super accurate (depending on the brand you buy).Between the two,I'd go with the '06.A .270 is plenty of gun though.The bolt action Rem 700 is highly accurate,it barely has any kick to it,and it will put 'em down(I use a 130 grain bullet).