Are you wanting to save the hides? Whatever ammo shoots most accurate in your rifle should be your choice as the .22-250 offers more than enough energy to humanely dispatch any coyote within any reasonable range you can hit them at. Personally I reload Nosler Ballistic Tips in the 40-50 grain range as I don't save the hides so whatever factory ammo that has bullets like this loaded will easily do the job. Usually BUT nowhere near always the "premium" offerings will obtain better accuracy in smaller varmint calibers such as your .22-250. The smaller the cartridge, the more persnickity they are, and more sensitive to load variations. It's been more years than I care to remember since I shot any factory ammo.