With my Vital Gear camelback pendulum, the instructions said to lock it down and sight the single pin at 25 yards, flat level ground. Then, you're good to go from 5 yards out to 30 yards - maybe 35 with a real fast bow. I've practiced from all ranges, and am a hair low at 30 yards from up in a treestand.

I have an '06 Reflex Highlander at 68#, 29" draw, and am shooting 267 (or 272 with feathers).