I have a Ruger Mark II Target (5.5"), a Ruger Mark I, a couple Browning Buckmarks, and I just bought a Walther P22 (3.5") yesterday.

I had no problem shooting a few cottontails this evening with the new P22, farthest one I head shot was about 35 yards tonight. My only complaint is the sights are a lil too large for the small P22, makes it a little tough to get used to with such a short sight radius compared to my other handguns.