Nolehoe
Of course I can not guarantee it (cause there are no reall guarantees in this world) but I believe the 250 GD will pass through a whitetail most times unless a major bone structure is hit. Whitetails anyway our white tials are really thin skinned animals. The 250 is a great bullet to 150 yards, it will expand to a given point and continue to drive through the animal, but a more important part it will do the same thing at 10 yards.
I am shooting the 250 GD @ 1860 fps with 100 grains of T7 and the 300 GD at 1750 fps. I would use the 300 for elk and ifthe shots are going to be 175 yards plus.
Actually either bullet is very effective - they will never be able to duplicate exactly what a Barnes or my Noslers can do - but they do not cost nearly as much either...
Here is a picture of the typical expansion - these were torture tested @ 100 yards into a saturated dirt (Palouse clay) water bar..