I have shot off two pounds of Black Horn 209 and it is a very impressive powder to shoot.

No swabbing of the barrel is needed.
Very powerful.
I had very good accuracy.
Easy to clean with a solvent.
No crud rings.

The draw backs..
1. cost = it comes in 10 ounces jugs and they go for on average $25.00 - $32.00 per jug.
2. it is not available in all areas. So make sure you have a source for it if you intend to shoot it. Or you can add a hazmat fee to the cost of the powder. That's an extra $25.00
3. breech plugs tend to carbon up and special attention must be paid to the fire channel in them.
4. you clean it with solvent. No water with this stuff.
5. only certain rifles and certain primers can handle the stuff. Make sure your rifle is one of them.

Triple Seven 2f loose powder is a hard powder to beat. It works good in all rifles, but there is the chance of a crud ring. But if you swab the barrel between shots the crud ring is not a problem. It is also in the $20.00+ range per pound and you can find it on sale for a lot less then that.

Pyrodex RS in powder or loose is a good powder. And you know how that acts.

APP (American Pioneer Powder, Shockey Gold, Pinnacle).. some rifles love this powder and some rifles don't. You will not know until you try it. Accuracy is excellent. Good power to it. Easy to clean. No crud ring. No swabbing.

So the best powder for you is the powder that is most accurate with your favorite and trusted projectile you hunt with.