Given the choice, for a do it all lower 48, I would choose 308. Including AK, I think I would go to the 30-06. For longer range lower 48, 300 WSM.

Another good choice would be 338 federal. I think the only thing it leaves wanting is a long Elk or Antelope shot. Other than that, pretty much ideal, IMO.

Bigger bullets always beat more velocity for killing, IME. Wanna shoot my 375 JDJ pistol?[:-]