ORIGINAL: cayugad
Personally if you want to make sure you stop them, go to a Barnes, Nosler, or even a Speer. I personally like a Hornady .44 caliber 300 grain XTP in a harvester sabot in my rifles. I think with 100 grains of powder and that bullet it will flatten a deer. But the deer in my area refuse to cooperate unless I am walking around with an old roundball shooter.
+1 on the Nosler, Barnes, Speer Gold Dot. I would shoot 300g to get pass thru and I would use a Barnes MZ 300g for < 150 shooting and if I had to shoot 200 I would use the new Barnes T-EZ 300g flat based bullet. The are expensive but do the job. The Noslers in 300g flat based HG are great also. I you shoot a heck of a lot, the go with the Speer Gold Dot 300g and use it with a Crushed Rib sabot. Best Wishes on your testing and selection.
Chap