If you want to save furs than do yourself a favor and work up a load with Sierra 55gr Gamekings #1365 bullets. These are tougher and will yield quarter sized exits that are easy to deal with. A close second choice would be the Hornady 52gr Match Hp. They usually don't exit, but will hold together and penetrate better than varmint type bullets. the 22-250 is a very good choice for killing coyotes and with the right bullet can be good for hides as well.