ORIGINAL: shooter50

I have a T/C Renegade .50cal 1:48 twist that I am planning on using with the iron sights next season when I hunt in the thicket where i hunt (30-50 yard shots). I am thinking about buying a GMB .54cal 1:70 twist in which I am planning on using PRB and installing a scope because I will have shots on average 75-100 yards with apossibility of a 100-150 yards (if its a trophy buck and the conditions are right). Anyway if I sight in the .50cal barrel and pop out the wegde pin install the .54cal barrel and sight it in with the scope can I switch barrels throughout the season without losing the zero on each barrel?