I have tried a lot of bullets and take over 120 deer, and discounting the brain and spine targets where any bullet will drop them it still comes down to a certain amount of bullet placement, hitting the area over the top of the heart where the major blood vessels all come together, from the side this takes out both lungs to. Now the original SW 250gr would do the job here I am not so sure about the bonded ones or the new ones the reports since they changed them have not been good, the noslers and the Gold Dot 250 have been very dependable, with a proper hit the gold Dot in my opinion is the most reliable drop them on the spot bullet out the, and the fact that they are reasonably priced compared to the dollar or more a piece bullets don't hurt my feelings either. Lee