Though I reload both of them....

Something else you might consider is WHICH varmint you're shooting? I prefer the .223 over the .22-250 on coyotes, since there's usually less post-shot "stitching" required on the other side of the pelt, if there's any at all.

Sitting in one spot shooting prairie dogs all day, the .22-250 rules. That is, unless the wind is blowing, then it's the .243.