i have an SPS Varmint in 22-250...

i LOVE it....great shooting rifle straight out of the box with a 6-18x40AOT Leupold on it...

CO Luckydog is correct....dont go with the SPS Varmint with the 26" heavy barrel if you plan to walk far and carry the rifle!!! VERY top heavy bare..put a big scope on it, and a harris bipod, and you have to sling it upside down for sure...then walking is tough...gotta watch brush and grass hitting the muzzle etc...but, i bought mine to reach out and touch...not to go for a walk! lol...i know the farmers in my area and most will let me drive their farmer roads and such...i can usually park not far from where i setup for groundhog hunting....

223 vs 22-250 can be debated till the cows come home....the 22-250 will give you a bit more range...but like CO said, not if you dont practice...even 200+ is more challenging than most give credit for...300+ takes a bit of knowledge and know how...ive found that if i dont practice somewhat regular, i get sloppy and cant make those 300+yd shots with much consistency....