My vote is for the 25-06, I have one and I can tell the 06 isa fine round. The 25-06 makes a ok varmit rifle, a little heavy on recoil for a all day praire shoot, but a awesome yote round. Its a great round for deer flat shooting and with enough pop to take a big one down way out yonder. The longest shot I have ever made on a deer was 418 yards and that was with my 25-06. I have a little experience with the .243 win and my opion is if the shots are kept to broadside and 250 yards and under you should have no problem. Now im sure there are a ton of people who will disagree with me on that,but I have seen the .243 fail on two raking shots of adult deer.One was found a week later dead and the other had to be put down with a 30-06. If I was using a .243 I think I would load up some nosler partitions for it, that might make all thedifference.As for the .260 I have no experience with it. I have shot a .264 win mag before, it uses the 6.5mm bullet. That calibur is all but gone now.n the wind now.