RE: Hornady low drag
VVVAAA,
The low drag sabots are thinner than the standard sabots. They are useful if the standard sabot loads 2-hands tight and needing pounding, to get down the barrel on a fouled barrel.
Otherwise, the bullet is the same.
Two things to consider: 1) ease of loading, 2) sufficient accuracy for your hunting conditions.
Only trial and experimentation with your rifle will determine which is best for you.
Have fun while working up a good load.