Kyle:

You are using 100 gr. powder and not (2) pyrodex pellets correct?

I use a TC Omega also.
.50 caliber
(2) pyrodex pellets
Hornady Sabot (not sure of all of the specs from here at work)

I do not have an accuracy issue, however, the entry and exit holes are usually small little holes.
I usually get no hair at impact and no blood trail for the first 50 yards.

I was actualy contemplating going back to the shotgun with 1oz. slugs.

Maybe I will try the TC Shockwave Sabots - just wondering how much difference the Pyrodex will make versus the powder.