I have shot deer on the other side of brush.The brush covered the kill zone,BUT I could still see the kill zone.The key was I KNOW my arrow trajectory and I shot OVER the brush and hit the heart and lungs of the doe.She went 20 yards.
The situation dictates the course of action I will take.
Know your eqipment,know your limitations,know the equipments limitations,know trajectory and make informed decisions from there.