My Ruger 5.5" Bisley has adjustable sights and no scopes on it for hunting. It is good to about 50 yards for me.

My dad has a Ruger SBH 10.5" barrel and a 4x scope on it. With this gun, I've taken deer out to 125 yards, but I think I would keep my shots under 100 next time. 125 is quite a ways.