in my opinion the difference between them all is really more theoretical then anything. For hunting in PA where I would imagine most of your shots are 300 yards and in, I doubt you will notice a big difference on game. All four of them will kill any deer or black bear dead as you please. 7mm 08 is probably a half step behind the 06, the 7 mag is probably a half step ahead of the 06, and the 300 win mag is a half step ahead of the 7 mag. All of them are great calibers though.