I have shot antelope, deer, bear, and elk with the .280.
Use 140 partitions for the light stuff and 160 partitions for the heavy stuff.
The animals can' t tell the difference out to 350 yards, beyond that the power levels between the 280 and the magnums can make a difference on the bigger animals. On deer and antelope you still have plenty of energy out to 500 yards (my personal range limit).

If I could only have one cartridge the 280 would be it.
If you reload try H4831sc, excellent in all bullet weights.
Good choice!!