I have each of those calibers and they will all do the job, they will all shoot great and all shoot out to 300yds, the 25-06 is going to have less drop than the other two at that range... My personal favorite is the 25-06 though, no particular reason but one is that my daughter can shoot it as the one I have is a varmint gun and is real heavy thus reducing the recoils for her... This last weekI took a buck, doe and a hog with it andallthree of those animalsdidn't go anywhere.... The week before that the wife took a doe and put her down right there too... Then again, all of those rounds will do that!!!