If it's all you have to shoot them with,just make sure it's head shot's only out to 100yards and I wouldn't make any chest shots and expect to find them,you will find some and some may drop dead in their tracks from a body shot but the more you shot the more you won't find,I have hunted coyote's for almost 12 years and killed many, and with a centerfire you will have a runner that can cover a hundred yards or more with his ribs blowed out their side.They are tough,and some people will tell you they hunt them with a .22lr and kill them everytime and they may,I have head shot two of them in my life while squirrel hunting with a .22,the first one folded like a lawn chair,then a few years later the second chance arrose the second one got it between the eyes at the same range about 40yards,the bullet turned him a flip and he took off so fast you couldn't have shot him with any kind of gun,so pick your shots,and good luck getting one to stand still for more than a few second's.This is my opinion based on my experiences with a rimfire,I killed two this summer at 151 yards while groundhog hunting with my 5mm rem. mag.I had no intentions of shooting a coyote,but the chance came along for me to take a link or two out of the food chain and I did,but I wouldn't take that rifle coyote hunting!! good luck and good hunting.