Although It would not be my first choice, I know quite a few good hunters who use the 22-250 for deer. There are at least three factory loads for the 22-250 that are intended for use on deer. People who have the disapline to choose thier shots carefully can get by with a 22-250 which is legal where I hunt. I have as much faith in my 22-250 as I do my 243 if not more. I would support a 25 caliber low limit.