ORIGINAL: instinct
I like my 7mm rem mag it is a little overkill to say the least but tracking deer is not done as much or hardly at all with this rifle.
+1 for 7 Mag or 300 Win (which I voted for) Hit 'em with that much gun, they just go down, and stay that way. Lot to be said for never having to trail a wounded animal. The sole caveat being that you take the time and practice to get good with such a large rifle. All that horsepower does no good in the wrong place.