Im going to have to disagree with you on part of your response. Its not necessary to use a 454,460, or 500. Especially the 500. I have shot the 500, 460 and 454 and the 454 is the max anyone would need to go. the minimum being 357. The better all around choice would be a .44 mag. Ive seen so many deer taken with a 44 and dropped on the spot its not funny. The 460 and 500 are just too much to carry. I shot the 500 once and will never shoot it again, I love shooting the 460 and 454.
ORIGINAL: MISwampDog
any .45 cal will kill a deer, just like a .22 will kill a deer. it all depends on distance and shot placement. Perosnally i would't use anything smaller than a .357 mag. now it's true that a .45 is a larger bullet, but it does not have the power that a .357 mag has. to be honest...if ur gunna hunt deer with a pistol get a 454, 460, or 500. Those hand guns will kill the deer no questions asked. do the animal a favor and take it out cleanly.