I think asking how a Hoyt stacked up with a Mathews is about like asking how a Ford Truck stacks up against the Chevy. Some will tell you the Hoyt is the way to go, others will tell you Mathews. The reality is that you have to try them both and see which one fits you the best. They are both very nice bows.
I tried both, and I preferred the Mathews. The Mathews grip fits me better and I don' t like the extra brace Hoyt puts on their bows (near the handguard). Your results may vary