.243 or 25-06. .243 with 85's or 100's would be perfect for yotes and goats and deer as well. 25-06 with 100-117 gr bullets for deer and goats.

I personally use 70 gr hp for yotes out of my .243 and 100 gr for deer. I use 100 and 117 gr sierra's out of my 25-308.