ORIGINAL: semi

I know i should resight in this situation but am looking for opinions...

I have been using 150 gr Corelokts for deer hunting for about 3 years in my M70 30.06. I started using this gr cuz i found a great deal on the ammo ($6 a box) a few years ago.

now i want to move up to 165 gr corelokts for this deer season. I won't have time to re-sight with my work schedule as i fly back in the day before opening day.

Will there be a huge difference in my accuracy? i think there could be but just wanted a more expert opinion. I am bring my other guns as well but sometimes i find the use for the 30.06 as my back up gun.