I shot a buck once on public land with a 12 gauge sluggun. I'm primarily a bowhunter so I aimed for a heart lungshot. The deer mulekicked and ran off. A couple minutes later (long after the deer was dead) I hear two shots. The buck had fallen in front of a guy who walked up and shot twice so he could clame it. It had my 12 gauge hole thru its heart (which came out in two peices) and his 308 tiny hole in it jaw. He said he hit it at a full run.

I like when they drop. I doubt you loose a ton of meat. But I'm still a bowhunter so I always aim at the lungs.