Heart and lung shot. First deer i shot i was aiming for the chest area but the buck moved at the last second and shot it in the head.. but as i said, i' d say heart/lung would be best. As other people mention a headshot is harder and the chance of messed up the antlers and such is greater. On my hunting game (Cabelas Big Game Hunter for the PS2) you can make head shot because it doesn' t ruin it lol. (I use bows, my dad uses 300. Mag.)