Cal,
Ask yourself what are you going to use it for?
Targets? Single shots are great.

Hunting? Single shots aren' t so great, that is unless of course you are perfect like most the hunters on this board and never miss and never wound, always drop them in their tracks, and never need a second shot.

On the 22-250 beware, varmit/target guns get their barrels " shot out" more frequently.

On the 375 HH, it has a built-in defence mechanism that discourages over usage, so you are probably safe there but 375HH? That is a hunting cartridge/caliber -- follow up shot.

You can get a new 375 HH in CZ in the low 600' s and oldelkhunter knows of one sitting on consignment.

Never Go Undergunned,
EKM