Bronko is right on. I have shot deer with a 243 up to a 300 win mag, all will kill a deer if hit in the right place. I shoot a 30-06 alot it is one of my favorite guns. I have had mine since I turned 16 and I feel I shoot it better than any other because I am so use to it. If you want a deer to drop in its tracks try to bust through both front shoulder. I dont take this shot because of so much meat loss, but it will shore put them done quick.