Many times!!!! I used to carry a .22LR revolver with me when hunting areas known to have wild dogs that were a little nasty, and several times I busted squirrels when the deer hunting wasn't going my way, and the squirrels were taunting me. I've also done it a few times with arrows, including one time when I took the little nut-muncher's tail off, only to have him fall from the tree DEAD as a doornail a few minutes later. Seems a squirrel CAN bleed to death from his tail if it's sharply cut off.