I've shot many many many many whitetails (large whitetails at that) with my 243, and out of the many many many many whitetails I've shot they've maybe all gone a combined 50 yards total. I'd say out of the deer I've shot I've dropped 97.5% in their tracks. This includes some 400+ yard shots on them as well.

I alternate between my 7mm Rem Mag (windy day gun) and my 243 (walking gun), and the terminal performance is always the same.

I use 95gr Combined Technology BTs pushed to max velocity.