i think it kinda depends on what state you are in..if your in northern states the deer have thicker winter coats and more fat..so im not to sure about how it works up there..but i hunt in arkansas and the 243 is all i ever use to use for a while..its a very accurate rifle..i dropped a deer 300 yards out with it..and many more..within the 100-200 yard range..but in the south the deer do not have as thick as a fat layer or winter coat..thats my experience with it..i even use to hunt with a 22-250while back..it mainly depends on shot placement..put it in the vitals and they are not goin far.