for big game I would take the 30-06 for deer I would take the 270 wsm.
Has anyone ever compared balistic gelatin tests. Theres not much that will out penetrate the 30-06.
I seen my friend shoot a buck with the 270 wsm using fusion ammo, deer was 60 yds away and the bullet exploded on entry, no exit but the deer didnt go far at all. Big ! entry hole.

Most will agree that higher velocity guns tend to under penetrate and bullets tend to explode, the solution, a bonded bullet, well now you have a bullet thats harder and stays together and penetrates, well you right back to square one with a non magnum cartridge. A magnum cartridge in standard bullets penetrate and expand perfect at long ranges, because of the slower velocity way out there at that range, this is where I think magnums shine, long range shooting. Put a hard bullet in a magnum, shoot long range and have the bullet slide between the ribs, what do you get, a pencil size hole.
Under 300 yds, standard calibers using standard bullets, above 300 yds, magnums and standard bullets would be my choice.