I have a pair of Ruger single action revolvers and I've done a little bit of experimenting with them.
I have a 5 5/8" barreled .41 mag and a 7 5/8" barreled 44 mag and my honest opinion, without scopes andusing factory hunting loads, resting on a treestand rest, a bipod or a fork in a tree, I can't tell a difference in the accuracy.

I've always heard that from a bench rest, with a good scope andwith super accurate hand loads you'll be able to tell the difference, but I probably won't do that. I use revolvers for hunting.

The longer barrel is a little heavier and will help with recoil and muzzle lift. AND the shorter barrel is absolutely handier to tote around a mountain or a up and down in a treestand.

There's my $.02!!