As said shot placement is key, BUT, to me, not as much as ammunition. One night me and my dad were riding around fields my cousin had said some hogs had moved into and were goin through. We would ride and everynow and then shine the light into the field. We came across a big 'ole boar wandering on his own heading to the creek as they had been. With my 7mmMag and a 150gr boat-tail hollow point, I put the cross hairs just behind the shoulder and put him down. He was broadside facing left. When I shot he spun to his right and fell on his right side, did a 180. At 134 yards there lay a 428 pound boar.
If you've got the right stuff, you can hit'em just like any other big game.

Good Luck