Early season in PA I'll whack any mature doe that stands still long enough.......in Illinois Greg and I are more particular about WHEN we'll shoot one while we hunt the pre-rut and rut.
IF we see a group of does on an evening hunt with no buck in sight we'll generally quietly try to take a mature one out.
AM hunts we dont' shoot them because we don't want to be tied down dealing with cleaning etc and screw up our afternoon buck hunting.

Lone does in the evening generally get a pass because they seem to usually be the ones with a buck trailing somewhere behind.