I am in the market for a new rifle. I not very saavy when it comes to which calibre is the best for an all around big game gun. I live in a shotgun only area for deer so the only real experience with rifles i have is with my .223's and .22-250 for predator hunting.

Which calibre would you guys recomend for anything from Whitetails to elk, The only limit to shooting distance will be my comfort level with the rifle.

Thanks for any input
Tom